At CCBM, undergraduate students, graduate students, postdoctoral fellows, faculty members, and summer CCBM fellows have access to state-of-the-art instruments for synthesis, characterization, and performance evaluation, after training and certification.
UC Merced’s compact campus includes four shared user facilities: the Imaging Microscopy Facility, the Environmental Analytical Lab, the Molecular Characterization Facility, and the Stem Cell Instrument Foundry.
Shared Facilities - University of California, Merced
This facility provides the tools for device fabrication such as a contact aligner, atomic layer deposition and profilometer.
The Stem Cell Instrumentation Foundry (SCIF) will provide advanced instruments, student training in cutting-edge techniques, and access to microfabrication collaborators. Selected six graduate scholars will be working in the Stem Cell Instrumentation Foundry’s (SCIF) cleanroom and cell culture labs for up to two weeks period and will primarily get trained on the photolithography and cell culture equipment. SCIF features are as follows:
The newly opened SCIF at UC Merced provides stem cell researchers at UC Merced and throughout California access to advanced instruments, techniques and collaborators for single cell analysis. The SCIF is housed on the main UC Merced campus in a 5420 square-foot facility which includes Class 1000 and 100 clean rooms for micro/nano fabrication, facilities for human and mouse stem cell culture, quantitative cell imagining, and workstations. The SCIF features clean-rooms for micro/nano fabrication and has essential fabrication equipment, providing a broad range of processing capabilities, including facilities for human and mouse stem cell culture and quantitative cell imaging. The facility is equipped with facilities for human and mouse stem cell culture, quantitative cell imaging, and workstations, Nikon TE-2000U inverted epi-fluorescence microscope with CoolSnap HQ2 camera, fluorescent microscopy and fluorescence cell scanning and sorting (FACS), a Laser Scanning Confocal Microscope, FACS cell sorters and analyzers (Aria and Guava) and an 11-color FACS scanner (BD LSR II), Focused Ion Beam, photolithography, acid sink, atomic layer deposition, JEOL Environmental SEM (ESEM), 1 standard X- ray generators, small angle unit, an EXAFS unit and equipment for single crystals or powders (from 2k to 2,500 K), lithography (down to 1.2 μm), vapor deposition systems, reactive ion etching and UV- ozonation tool, and wet chemical processing. Researchers also have access to a wide range of offerings enabling them to rapidly adopt groundbreaking research technologies, connect to online support, workshops and collaborators, conduct computational biology and make new discoveries and develop molecular tools and approaches that will be broadly applicable for basic and applied science and regenerative medicine.
The SCIF is particularly unique because it provides a range of microfluidic-based systems enabling researchers, with no prior knowledge of micro/nano techniques, to custom design devices online to their specific needs, rapidly adopting cutting edge research technologies. Ancillary core services include materials characterization, a vivarium, and computational biology.
Selected six graduate scholars will be working in the Stem Cell Instrumentation Foundry’s (SCIF) cleanroom and cell culture labs for up to two weeks period and will primarily get trained on the photolithography and cell culture equipment.
Advanced imaging instruments such as Zeiss Gemini 500 scanning electron microscope with sub nanometer resolution, JEOL JR-2010 high-resolution transmission electron microscope and X-ray diffractometry (PANalytical X’Pert PRO Theta/Theta X-ray Diffraction).
Researchers in physical and biological sciences, as well as engineers, use the lab, which has a particular focus on nanotechnology. Student and faculty researchers find a range of materials characterization techniques, including advanced imaging, elemental analysis and structure determination and can use or be trained in the use of electron microscopes, scanning electron microscopes and transmission electron microscopes (SEM and TEM), atomic force microscope (AFM), small angle X -ray diffraction spectroscopy, raman spectroscopy, atomic force microscopy, dynamic light scattering system.
The Center will also leverage existing partnerships between faculty and academia and national laboratories at the following institutions: University of California, Davis, SLAC National Accelerator Laboratory, and Lawrence Berkeley National Lab.
The Molecular Characterization Facility houses several major instruments, including 400 MHz, 500 MHz and 600 MHz NMR spectrometers, a Horiba Fluorolog 3 fluorimeter, a Bruker Vertex 70 FT-IR spectrometer with a diamond crystal ATR accessory, a high resolution Thermo Electron Exactive Plus LC-MS for detecting small molecules, and a Q Exactive quadrupole Orbitrap LC-MS for high resolution detection of macromolecules.
Researchers can search for major and trace elements, selected chemical species and nutrients and organic compounds.
UC Merced faculty have access to a 800 MHz Avance III Spectrometer located on the campus of the University of California, Davis, approximately a 2-hour drive north of Merced, CA. The facility is equipped with with a Bruker TCI cryoprobe that provides about a 4:1 Signal-to-Noise improvement over conventional probes. It is highly suited for metabolomic studies, the study of complex biomolecules like proteins and nucleic acids, and routine 1H and 13C NMR experiments on small molecules.
The Stanford Synchrotron Radiation Lightsource (SSRL) is a multi-program national laboratory exploring frontier questions in photon science, astrophysics, biochemistry, material science, particle physics and accelerator research, and provides synchrotron radiation, a name given to X-rays or light produced by electrons circulating in a storage. These extremely bright x-rays serve as a resource for researchers to perform studies at the atomic and molecular level. Synchrotron radiation laboratories are also used for x- ray scattering and diffraction experiments. SSRL also provides unique educational experiences and serves as a vital training ground for future generations of scientists and engineers.
The Molecular Foundry, which houses the state-of-art imaging, synthetic, characterization and modeling capability supports major instrumentation such as, AB SCIEX TF4800 MALDI TOF-TOF Mass Spectrometer, Bruker Avance II 500 MHZ NMR Spectrometer, Lakeshore CPX-HF Superconducting Magnet-Based Horizontal Field Cryogenic Probe Station, Photovoltaic Test Station, Bruker MICROTOF- Q Mass Spectrometer, NanoLog Spectrofluorometer, MBRAUN Thermal Evaporator and VEECO DEKTAK 150 Profilometer and JEOL 2100-F 200 kV Field-Emission Analytical Transmission Electron Microscope and Zeiss Libra 120 Cryo-TEM and Zeiss Gemini Ultra-55 Analytical Field Emission Scanning Electron Microscope, PHI 5400 X-ray Photoelectron Spectroscopy (XPS) System, and Lorentz TEM for high-resolution electron microscopy with in situ XRD capabilities and magnetic field for structural and functional characterizations.
Science and Engineering Building 1
SE1 is a 4-story, 211,679 gross square-foot building located in the core section of campus. The SE1 building was awarded LEED Gold certification in February of 2009. The building includes laboratories, laboratory support space, teaching laboratories and offices and administrative office space for the PI and named senior personnel. Faculty members are assigned space in modern collaborative inter-disciplinary suites equipped with state of the art equipment. Sophisticated shared equipment is located in dedicated rooms within a suite with similar research needs or across-suites to encourage efficient utilization of resources and foster inter-disciplinary interactions.
Science and Engineering Building 2
SE2 is a 3-story, 102,000 square-foot facility overlooking the next phase of campus development. The building recently opened in 2014. It provides space for the School of Engineering Dean suite, School of Natural Sciences and School of Engineering faculty offices, graduate student and trainee offices, research and instructional laboratories, and corefacilities. Architectural features include several significant outdoor spaces, such as a pedestrian plaza; a solar-panel shaded promontory that can serve as an event venue; and a porch for outdoor learning opportunities. In addition to offices and labs on the upper levels, breakout rooms with adjacent balconies will provide collaboration space featuring sweeping vistas of the undeveloped landscape and future campus expansion.
Classroom and Office Building
COB is a 3-story, 104,369 gross square-foot building with classrooms, offices, and laboratories. The COB was awarded LEED Gold Certification in March of 2008. COB1 is a 3-story, 104,369 gross square foot building located in the core section of campus.
Social Sciences and Management
SSM is a 3-story, 105,781 gross square-foot building houses the School of Social Sciences, Humanities and Arts. SSM has 61,900 assignable square feet of classrooms, teaching laboratories, offices, and administrative office space, research and scholarly activity space to support continued growth in the SchoolofSocialSciences,HumanitiesandArts.Inaddition,ithousesa smallartgallery,artstudios and unique meeting spaces.
KL is a 4-story, 180,000 square-foot building houses the campus library and meeting rooms in the four- story east wing, and administrative offices and student services space in the three-story west wing. Additionally, executive campus leadership and administration, a large public gathering spaces and common dining area, and campus bookstore are located within the building. The library has 17 group meeting rooms, and dedicated study space and library instruction. As part of the University of California, UC Merced Library shares resources with other campuses and has developed much of its electronic collection in conjunction with the California Digital Library (CDL). The library offers 48 laptops for instruction, 10 public workstations that visitors can use to access library information online, and 2 high resolution book scanners.
In addition to the main campus, there are off-campus research facilities where CCBM student training will take place. The Castle Research Facility in Atwater, CA accommodates campus research overflow.
CCBM facilities include CCBM Workstation with Merced clusters in SE 142, Confocal Microscope and Mass Spec.
For all CCBM affiliated faculty, project scientists, post-docs, graduate students and undergraduates.