Multidisciplinary Research
Chemistry, physics, biology, and engineering fields—to study how biological matter assembles to perform specific tasks, in hopes of eventually being able to engineer and develop innovations (from designer cells and tissue to novel diagnostic and therapeutic devices)
The NSF CREST Center for Cellular and Biomolecular Machines focuses on three specialized research areas in Phase II: Protein Metamorphosis and Responsive Nanodevices, Adaptive and Responsive Mesoscale Assemblies, and Adaptive Cellular Communication.
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Thrust 1 Faculty Eva de Alba Bastarrechea, Lead Roberto Andresen Eguiluz Michael Colvin Aaron Hernday Andy LiWang Patricia LiWang Andrea Merg Victor Muñoz Tomas Rube Anand Bala Subramaniam Shahar Sukenik Michael C. Thompson
Faculty Affiliates Juris Grasis
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Thrust 2 Faculty Ryan Baxter Kinjal Dasbiswas, Lead Sayantani Ghosh Ajay Gopinathan Linda Hirst Kevin Mitchell Maxime Theillard Tao Ye
Faculty Affiliates N/A |
Thrust 3 Faculty Roberto Andresen Eguiluz Daniel Beller Kinjal Dasbiswas Xuecai Ge Arvind Gopinath Ajay Gopinathan Bin Liu Kara McCloskey Suzanne Sindi Joel Spencer Fred Wolf Stephanie Woo, Lead
Faculty Affiliates N/A |
Thrust 1: Protein Metamorphosis and Responsive Nanodevices
Thrust 1: Protein Metamorphosis and Responsive Nanodevices.
Phase II research focuses on the emerging theme of protein metamorphosis as mechanism to enable natural and synthetic controllable biological nanodevices, organized in two broad areas: the functional roles of gradually morphing proteins; and engineering of control systems of the assembly-disassembly of biological macromolecular assemblies.
Thrust 2: Adaptive and Responsive Mesoscale Assemblies
Thrust 2: Adaptive and Responsive Mesoscale Assemblies.
In Phase II, the focus is to understand the mechanisms that enable assemblies to function collectively in adaptive and responsive ways as well as exploiting them for applications.
Thrust 3: Adaptive Cellular Communication
Thrust 3: Adaptive Cellular Communication.
Phase II will examine the impact of cell-cell and cell-matrix mechanical interactions on collective cell motility, patterning and the emergence of function, combining experimental and modeling approaches.
